Cook G C
Trans R Soc Trop Med Hyg. 1978;72(3):277-81. doi: 10.1016/0035-9203(78)90208-0.
Thirty-six hospital in-patients in London had breath-hydrogen concentrations measured after 50 g lactose were given orally; in 23 or them serial blood glucose concentrations were also estimated. Eight had tropical malabsorption (TM), 14 were Europeans with no detectable disease (normal group) and 14 who also had no detectable disease, were from ethnic groups known to have a very high incidence of genetically determined adult hypolactasia (hl). In 21 of them breath-hydrogen concentrations were also measured after 33.5 g of lactulose were given orally. There was a good inverse correlation between breath-hydrogen production and blood-glucose rise after lactose. Correlations between the first appearance of hydrogen (T) and the area under the hydrogen curve between 0 and 120 min (A) were inversely significant both for lactose and lactulose. Mean T was earlier and mean A greater for lactose compared with lactulose. Correlation between individual values for A after lactase and after lactulose was significant. Indirect measurements of lactase are of no value in either detecting or assessing the severity of TM; that is largely due to the very high incidence of HL in individuals exposed to that disease.
在伦敦，36名住院患者口服50克乳糖后测量了呼出气氢气浓度；其中23名患者还测定了连续血糖浓度。8名患有热带吸收不良（TM），14名是未检测出疾病的欧洲人（正常组），另外14名同样未检测出疾病，但来自已知遗传性成人乳糖酶缺乏症（hl）发病率非常高的种族群体。其中21人还口服33.5克乳果糖后测量了呼出气氢气浓度。乳糖后呼出气氢气产生量与血糖升高之间存在良好的负相关。乳糖和乳果糖的氢气首次出现时间（T）与0至120分钟之间的氢气曲线下面积（A）之间的相关性均呈显著负相关。与乳果糖相比，乳糖的平均T更早，平均A更大。乳糖酶和乳果糖后A的个体值之间的相关性显著。乳糖酶的间接测量在检测或评估TM的严重程度方面均无价值；这主要是由于接触该疾病的个体中hl的发病率非常高。
