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刺激关联对清醒猫皮层听觉感受神经元电流活性和兴奋性的影响

Activity and excitability to electrical current of cortical auditory receptive neurons of awake cats as affected by stimulus association.

作者信息

Woody C D, Knispel J D, Crow T J, Black-Cleworth P A

出版信息

J Neurophysiol. 1976 Sep;39(5):1045-61. doi: 10.1152/jn.1976.39.5.1045.

DOI:10.1152/jn.1976.39.5.1045
PMID:978236
Abstract
  1. Unit activity and excitability were studied at the midlateral and suprasylvian cortex of naive, blink-conditioned and "randomization" cats. The latter received the same CS and US as did the conditioned animals, but in random temporal order and with random intertrial intervals with mean comparable to that used for conditioning. The randomization group failed to develop a blink CR. 2. With conditioning, spontaneous and evoked unit discharges were increased above levels found in naive animals. Correspondingly, levels of extracellularly injected current required to elicit a spike discharge were lower in conditioned than in naive animals. In addition, in the conditioned animals, the degree of enhancement of evoked activity and excitability was found to be greatest in the units that responded to the CS, as opposed to units that responded to another auditory stimulus of equal intensity but of no special behavioral significance vis-a-vis the conditioned reflex. 3...
摘要
  1. 研究了未经过训练的、眨眼条件反射的和“随机化”猫的外侧中回和上薛氏回皮质的单位活动和兴奋性。后者接受与条件反射动物相同的条件刺激（CS）和非条件刺激（US），但呈现时间随机，且每次试验间隔时间也随机，其平均间隔时间与用于条件反射训练的相当。随机化组未能形成眨眼条件反射。2. 通过条件反射训练，自发和诱发的单位放电高于未经过训练动物的水平。相应地，引发动作电位发放所需的细胞外注入电流水平，在经过条件反射训练的动物中比未经过训练的动物要低。此外，在经过条件反射训练的动物中，发现对条件刺激有反应的单位，其诱发活动和兴奋性的增强程度最大，这与对同等强度但相对于条件反射无特殊行为意义的另一种听觉刺激有反应的单位形成对比。3...

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