胆碱能位点：胆碱乙酰转移酶（ChAT）和囊泡乙酰胆碱转运体（VAChT）基因
The cholinergic locus: ChAT and VAChT genes.
作者信息
Mallet J, Houhou L, Pajak F, Oda Y, Cervini R, Bejanin S, Berrard S
机构信息
CNRS, Laboratoire de Génétique de la Neurotransmission et des Processus Neurodégénératifs, Hôpital Pitié-Salpétrière, Paris, France.
出版信息
J Physiol Paris. 1998 Apr;92(2):145-7. doi: 10.1016/S0928-4257(98)80153-8.
The gene encoding the vesicular acetylcholine transporter has been localized within the first intron of the gene encoding choline acetyltransferase and is in the same transcriptional orientation. These two genes, whose products are required for the expression of the cholinergic phenotype, could therefore be coregulated. The promoters of both genes have been identified. The mechanisms that account for the regulation of the expression of both genes are now being investigated.
编码囊泡乙酰胆碱转运体的基因已定位在编码胆碱乙酰转移酶的基因的第一个内含子内，且转录方向相同。因此，这两个基因（其产物是胆碱能表型表达所必需的）可能受到共同调控。现已鉴定出这两个基因的启动子。目前正在研究调控这两个基因表达的机制。
Zotero 插件