从胆碱能基因位点到胆碱能神经元。

From the cholinergic gene locus to the cholinergic neuron.

作者信息

Weihe E, Schäfer M K, Schütz B, Anlauf M, Depboylu C, Brett C, Chen L, Eiden L E

机构信息

Department of Anatomy and Cell Biology, Philipps University, Marburg, Germany.

出版信息

J Physiol Paris. 1998 Oct-Dec;92(5-6):385-8. doi: 10.1016/S0928-4257(99)80010-2.

DOI:10.1016/S0928-4257(99)80010-2

PMID:9789842

Abstract

The cholinergic gene locus (CGL) was first identified in 1994 as the site (human chromosome 10q11.2) at which choline acetyltransferase and a functional vesicular acetylcholine transporter are co-localized. Here, we present recent neuroanatomical, developmental, and evolutionary insights into the chemical coding of cholinergic neurotransmission that have been gleaned from the study of the CGL, and its protein products VAChT and ChAT, which comprise a synthesis-sequestration pathway that functionally defines the cholinergic phenotype.

摘要

胆碱能基因位点（CGL）于1994年首次被确定为胆碱乙酰转移酶和功能性囊泡乙酰胆碱转运体共定位的位点（人类染色体10q11.2）。在此，我们展示了从对CGL及其蛋白质产物VAChT和ChAT的研究中获得的关于胆碱能神经传递化学编码的最新神经解剖学、发育学和进化学见解，它们构成了一个在功能上定义胆碱能表型的合成-隔离途径。