Rodríguez de Fonseca F, Navarro M
Institute for Drug Dependence Research, Department of Psychobiology, Faculty of Psychology, University Complutense, Madrid, Spain.
Ann Med. 1998 Aug;30(4):397-405. doi: 10.3109/07853899809029940.
The limbic system is a group of structurally and functionally related areas of the brain that provides the anatomical substrate for emotions and motivated behaviour, including the circuitry for the stress response and reward-related events. This system is strongly implicated in drug abuse from the pleasure and/or positive side associated with acute exposure to the dysphoria and craving associated with withdrawal. The contribution of the main cortical and subcortical elements of the limbic system to drug dependence is briefly reviewed in the present work with a focus on the role of the extended amygdala and its connections as well as on the peripheral feedback signals mediated by adrenal glucocorticoids. The elucidation of the neuroadaptive responses of the limbic system to chronic drug exposure will undoubtedly help to design rational strategies for the treatment of addiction.
边缘系统是大脑中一组在结构和功能上相关的区域，它为情绪和动机行为提供了解剖学基础，包括应激反应和与奖赏相关事件的神经回路。该系统与药物滥用密切相关，这源于急性接触药物时产生的愉悦感和/或积极效应，以及戒断时出现的烦躁不安和渴望。本文简要回顾了边缘系统主要皮质和皮质下成分对药物依赖的作用，重点关注了扩展杏仁核及其连接的作用，以及肾上腺糖皮质激素介导的外周反馈信号。阐明边缘系统对慢性药物暴露的神经适应性反应无疑将有助于设计合理的成瘾治疗策略。
