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一种针对唾液薄膜和血小板的链球菌黏附系统。

A streptococcal adhesion system for salivary pellicle and platelets.

作者信息

Gong K, Ouyang T, Herzberg M C

机构信息

Department of Preventive Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.

出版信息

Infect Immun. 1998 Nov;66(11):5388-92. doi: 10.1128/IAI.66.11.5388-5392.1998.

Abstract

A Streptococcus sanguis 133-79 adhesin identified by the monoclonal antibody 1.1 (MAb 1.1) binds both saliva-coated hydroxylapatite (sHA) and platelets. The complementary binding site(s) for the adhesin was identified by the anti-idiotypical MAb 2.1. To learn if this adhesion system, marked by the antiadhesin MAb 1.1 and anti-binding site MAb 2.1, is commonly used by strains within the sanguis group and other viridans group streptococci, 42 strains from seven species were tested. Strains that bind to both sHA and platelets use the same adhesin and binding site epitopes. Strains that do not adhere to platelets rely on other adhesin specificities to bind to sHA.

摘要

由单克隆抗体1.1(MAb 1.1)鉴定的血链球菌133 - 79粘附素可同时结合唾液包被的羟基磷灰石(sHA)和血小板。抗独特型单克隆抗体2.1鉴定出了该粘附素的互补结合位点。为了解以抗粘附素单克隆抗体1.1和抗结合位点单克隆抗体2.1为标志的这种粘附系统是否为血链球菌群及其他草绿色链球菌群内的菌株所常用,对来自7个物种的42株菌株进行了检测。能同时结合sHA和血小板的菌株使用相同的粘附素和结合位点表位。不粘附于血小板的菌株则依靠其他粘附素特异性来结合sHA。

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