Radeke H S, Snapper M L
Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02167-3860, USA.
Bioorg Med Chem. 1998 Aug;6(8):1227-32. doi: 10.1016/s0968-0896(98)00100-x.
The marine sponge metabolite ilimaquinone (1) displays a broad range of biological activities. To better understand the effects of this natural product, a photoaffinity analogue was synthesized and used to probe the cellular interactions of ilimaquinone. Irradiation of photoaffinity probe 5 with liver cytosol in the presence and absence of excess competitive inhibitor 2 suggests that S-adenosylhomocysteinase is an important intracellular target of ilimaquinone.
海洋海绵代谢产物伊利马醌（1）具有广泛的生物活性。为了更好地理解这种天然产物的作用，合成了一种光亲和类似物并用于探究伊利马醌的细胞相互作用。在存在和不存在过量竞争性抑制剂2的情况下，用光亲和探针5与肝细胞溶胶进行辐照，结果表明S-腺苷同型半胱氨酸酶是伊利马醌重要的细胞内靶点。
