Harley V S, Dance D A, Tovey G, McCrossan M V, Drasar B S
London School of Hygiene and Tropical Medicine, Great Britain.
Microbios. 1998;94(377):35-45.
Burkholderia pseudomallei causes melioidosis and is believed to be an intracellular pathogen in human and animal disease. The uptake of B. pseudomallei by mouse peritoneal macrophages and cells in tissue culture was examined by electron microscopy. In all the systems studied B. pseudomallei were phagocytosed and apparently inhibited the normal processes of intracellular killing. Destruction of the phagosome membrane occurred and the bacteria escaped into the cytoplasm.
类鼻疽伯克霍尔德菌可引起类鼻疽，被认为是人类和动物疾病中的一种细胞内病原体。通过电子显微镜检查了小鼠腹膜巨噬细胞和组织培养细胞对类鼻疽伯克霍尔德菌的摄取情况。在所有研究的系统中，类鼻疽伯克霍尔德菌都被吞噬，并且明显抑制了细胞内正常的杀伤过程。吞噬体膜遭到破坏，细菌逸出到细胞质中。
