Roy A
Psychiatry Service, Department of Veterans Affairs Medical Center, East Orange, NJ 07019, USA.
Biol Psychiatry. 1998 Oct 1;44(7):633-7. doi: 10.1016/s0006-3223(97)00509-x.
Depression is common among recently abstinent alcoholics; however, its treatment has been little studied.
Thirty-six depressed recently abstinent alcoholics were randomized in a 6-week double-blind placebo-controlled trial of sertraline 100 mg daily.
There was a significant group x time interaction for both the Hamilton Depression Rating Scale (HDRS) and the Beck Depression Inventory (BDI). For the HDRS there were significant differences between the sertraline and placebo groups at weeks 3 and 6 and for the BDI at week 3. Also, patients receiving sertraline had significantly lower mean posttreatment HDRS and BDI scores than patients receiving placebo. Furthermore, significantly more of the patients receiving sertraline obtained a Clinical Global Impression rating of "very much improved."
Depressed recently abstinent alcoholics benefit from antidepressant medication.
抑郁症在近期戒酒的酗酒者中很常见；然而，其治疗方法鲜少被研究。
36名近期戒酒且患有抑郁症的酗酒者被随机分配至一项为期6周的双盲安慰剂对照试验，试验中他们每日服用100毫克舍曲林。
汉密尔顿抑郁量表（HDRS）和贝克抑郁量表（BDI）均显示出显著的组×时间交互作用。对于HDRS，舍曲林组与安慰剂组在第3周和第6周存在显著差异，对于BDI，在第3周存在显著差异。此外，接受舍曲林治疗的患者治疗后的HDRS和BDI平均得分显著低于接受安慰剂治疗的患者。此外，接受舍曲林治疗的患者中获得“显著改善”临床总体印象评级的人数明显更多。
近期戒酒且患有抑郁症的酗酒者可从抗抑郁药物治疗中获益。
