Mühlhauser I, Overmann H, Bender R, Bott U, Jörgens V, Trautner C, Siegrist J, Berger M
Department of Metabolic Diseases and Nutrition (WHO-Collaborating Centre for Diabetes, Heinrich-Heine University, Düsseldorf, Germany.
Diabetologia. 1998 Oct;41(10):1139-50. doi: 10.1007/s001250051043.
The objective of this study was to assess the degree of diabetes care and education achieved for Type I (insulin-dependent) diabetes mellitus at the community level in relation to social status and to elucidate potential pathways that mediate any social class gradient. A population-based sample of 684 adults with Type I diabetes (41% women, mean +/- SD age 36 +/- 11, diabetes duration 18 +/- 11 years) in the district of North-Rhine (9.5 million inhabitants), Germany, were examined in their homes using a mobile ambulance.
HbA1c (normal 4.3-6.1%) 8.0 +/- 1.5%, incidence of severe hypoglycaemia (injection of glucose or glucagon) 0.21 cases per patient-year; 62% of patients had participated in a structured group treatment and teaching programme for intensification of insulin therapy; 70% used 3 or more insulin injections per day, 9% were on continuous subcutaneous insulin infusion; 91% reported to have had measurements of HbA1c during the preceding year, and 80% to have had an examination of the retina by an ophthalmologist. Care was insufficient with respect to the quality of blood pressure control (70% of patients on antihypertensive drugs had blood pressure values > or = 160/95 mmHg), patient awareness of proteinuria/albuminuria (27% of patients had not heard about it) and prevention of foot complications (only 42% with a diabetes duration over 10 years had remembered to have a foot examination during the preceding 12 months). There was a pronounced social gradient with respect to micro- and macrovascular complications (prevalence of overt nephropathy 7 vs 20% for highest vs lowest quintiles of social class [OR 3.5, 95% CI 1.6-7.5, p = 0.002]) and diabetes-specific quality of life. HbA1c, blood pressure and smoking accounted for part of the association between social class and microvascular complications. The social class gradient was not due to inequality to access to health services, but to lower acceptance among low social class patients of preventive and health maintaining behaviour. In conclusion, achieved standards of care are high with respect to the implementation of intensified treatment regimens, the level of patient education achieved, treatment control and eye care, whereas areas for improvement are blood pressure control and preventive measures for foot care. A substantial social gradient in diabetes care persists despite equal access of patients to health services.
本研究的目的是评估在社区层面,与社会地位相关的I型(胰岛素依赖型)糖尿病的护理和教育程度,并阐明介导任何社会阶层梯度的潜在途径。在德国北莱茵地区(950万居民),以人群为基础抽取了684名成年I型糖尿病患者(41%为女性,平均年龄±标准差为36±11岁,糖尿病病程为18±11年),使用移动救护车在其家中进行检查。
糖化血红蛋白(正常范围4.3 - 6.1%)为8.0±1.5%,严重低血糖(注射葡萄糖或胰高血糖素)的发生率为每位患者每年0.21例;62%的患者参加了强化胰岛素治疗的结构化小组治疗和教学计划;70%的患者每天使用3次或更多次胰岛素注射,9%的患者采用持续皮下胰岛素输注;91%的患者报告前一年进行了糖化血红蛋白测量,80%的患者接受了眼科医生的视网膜检查。在血压控制质量方面护理不足(70%服用降压药的患者血压值≥160/95 mmHg),患者对蛋白尿/白蛋白尿的知晓率(27%的患者未听说过)以及足部并发症的预防(糖尿病病程超过10年的患者中,只有42%记得在前12个月内进行过足部检查)。在微血管和大血管并发症(显性肾病的患病率,社会阶层最高五分位数与最低五分位数分别为7%和20%[比值比3.5,95%置信区间1.6 - 7.5,p = 0.002])以及糖尿病特异性生活质量方面存在明显的社会梯度。糖化血红蛋白、血压和吸烟在一定程度上解释了社会阶层与微血管并发症之间的关联。社会阶层梯度并非由于获得医疗服务的不平等,而是由于低社会阶层患者对预防和保健行为的接受程度较低。总之,在强化治疗方案的实施、患者教育水平、治疗控制和眼科护理方面,所达到的护理标准较高,而需要改进的方面是血压控制和足部护理的预防措施。尽管患者获得医疗服务的机会均等,但糖尿病护理中仍存在显著的社会梯度。