Darling R C, Dylewski M, Chang B B, Paty P S, Kreienberg P B, Lloyd W E, Shah D M
Albany Medical College, Division of General Surgery, New York 12208, USA.
Cardiovasc Surg. 1998 Oct;6(5):448-52. doi: 10.1016/s0967-2109(98)00030-1.
Patients who present for coronary artery bypass grafting with hemodynamically significant carotid artery lesions pose a difficult problem for both the cardiac and vascular surgeons. There is no consensus as to the proper management of these patients despite numerous studies. Prospective collection of data was performed in patients undergoing combined carotid endarterectomy and coronary artery bypass grafting's from April 1980 to November 1996. A total of 470 simultaneous carotid endarterectomy's and coronary artery bypass grafting's were performed in 420 patients. The average age of the patient was 69 years, with 62% being male, 15% being diabetic and 38% being smokers. Sixty (13%) presented with Transient ischemic attacks, 22 (5%) presented with amaurosis fugax, 16 (3.4%) presented with a prior history of stroke and 372 (70%) were asymptomatic. Operative mortality was 2.4% or 10 patients; 90% of those patients died from cardiac complications postoperatively and one patient died of a stroke. Permanent neurological deficits occurred in five (1%) of the patients, and six (1.7%) of the patients had a transient neurological deficit that improved prior to discharge. In conclusion, in our experience simultaneous carotid endarterectomy with coronary artery bypass grafting can be performed with an acceptable mortality and morbidity and does not appear to put the patient at a higher risk than when either procedure is performed alone.
因血流动力学显著的颈动脉病变而接受冠状动脉旁路移植术的患者,给心脏外科医生和血管外科医生都带来了难题。尽管有众多研究,但对于这些患者的恰当管理尚无共识。从1980年4月至1996年11月,对接受颈动脉内膜切除术和冠状动脉旁路移植术联合手术的患者进行了前瞻性数据收集。420例患者共进行了470次同期颈动脉内膜切除术和冠状动脉旁路移植术。患者的平均年龄为69岁,男性占62%,糖尿病患者占15%,吸烟者占38%。60例(13%)出现短暂性脑缺血发作,22例(5%)出现一过性黑矇,16例(3.4%)有既往卒中史,372例(70%)无症状。手术死亡率为2.4%,即10例患者死亡;其中90%的患者术后死于心脏并发症,1例患者死于卒中。5例(1%)患者出现永久性神经功能缺损,6例(1.7%)患者出现短暂性神经功能缺损,出院前有所改善。总之,根据我们的经验,同期进行颈动脉内膜切除术和冠状动脉旁路移植术的死亡率和发病率可以接受,而且与单独进行任何一种手术相比,似乎并未使患者面临更高风险。