Saika S, Miyamoto T, Kimura M, Ohmi S, Ohkawa K, Kawashima Y, Ohnishi Y, Ooshima A, Yamanaka A
Department of Ophthalmology, Wakayama Medical College, Japan.
J Cataract Refract Surg. 1998 Oct;24(10):1396-8. doi: 10.1016/s0886-3350(98)80236-8.
To evaluate the role of lens epithelial cells (LECs) in posterior capsule opacification.
Departments of Ophthalmology and Pathology, Wakayama Medical College, Department of Anatomy, Kansai Shinkyu College, and Department of Ophthalmology, Kobe Kaisei Hospital, Japan.
We examined the presence of degenerated LECs on the capsules of the eyes of rabbits and a patient after intraocular lens (IOL) implantation. Phacoextraction of a crystalline lens and IOL implantation were done in 5 albino rabbits under general anesthesia. The animals were killed after 2 months. Lens capsules were removed and fixed. During vitreous surgery, a lens capsule with an IOL was removed from a patient. Ultrathin sections of specimens were studied by transmission electron microscopy.
Presumed LECs proliferated between the posterior capsule and the IOL in association with collagenous matrix. Debris from the degenerated cells and destroyed intracellular organelles was also seen.
Lens epithelial cells proliferating on the posterior capsule cannot survive indefinitely.
评估晶状体上皮细胞（LECs）在晶状体后囊膜混浊中的作用。
日本和歌山县立医科大学眼科与病理科、关西神久学院解剖学系以及神户海星医院眼科。
我们检查了兔眼和1例患者眼内植入人工晶状体（IOL）后囊膜上变性的LECs的存在情况。在全身麻醉下对5只白化兔进行晶状体超声乳化吸出及IOL植入。2个月后处死动物。取出晶状体囊膜并固定。在玻璃体手术中，从1例患者眼中取出带IOL的晶状体囊膜。通过透射电子显微镜研究标本的超薄切片。
推测的LECs在后囊膜与IOL之间增殖，并伴有胶原基质。还可见到变性细胞的碎片和被破坏的细胞内细胞器。
在后囊膜上增殖的晶状体上皮细胞不能无限期存活。
