Nagao M, Kato S, Oda M, Hirai S
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Fuchu, Japan.
Acta Neuropathol. 1998 Oct;96(4):388-94. doi: 10.1007/s004010050909.
To investigate the origin of grumose (foamy) spheroid bodies (GFSB), the expression of two proteins associated with axonal regeneration, i.e., phosphotyrosine and 25-kDa synaptosomal-associated protein (SNAP-25), was immunohistochemically assessed in GFSB in the substantia nigra pars reticulate (SNPR) of progressive supranuclear palsy (PSP). Phosphotyrosine immunoreactive (-IR) and SNAP-25-IR were found in many GFSB. Both were expressed intensely on eosinophilic debris and grumose aggregates in GFSB. Our result suggests that GFSB are structures associated with aberrant sprouting of axons in the degenerated SNPR from other regions such as the globus pallidus to the SNPR, and that the aberrant sprouting may be associated with cell signaling involving tyrosine kinase systems.
为研究颗粒状（泡沫状）球体（GFSB）的起源，采用免疫组织化学方法评估了与轴突再生相关的两种蛋白质，即磷酸酪氨酸和25 kDa突触体相关蛋白（SNAP - 25）在进行性核上性麻痹（PSP）黑质网状部（SNPR）的GFSB中的表达。在许多GFSB中发现了磷酸酪氨酸免疫反应性（-IR）和SNAP - 25 - IR。二者在GFSB的嗜酸性碎片和颗粒状聚集体上均有强烈表达。我们的结果表明，GFSB是与从其他区域（如苍白球）到退变的SNPR的轴突发芽异常相关的结构，并且这种异常芽生可能与涉及酪氨酸激酶系统的细胞信号传导有关。
