Zhu X H, Kim S G, Andersen P, Ogawa S, Uğurbil K, Chen W
Center for Magnetic Resonance Research, University of Minnesota School of Medicine, Minneapolis 55455, USA.
Magn Reson Med. 1998 Nov;40(5):703-11. doi: 10.1002/mrm.1910400510.
A relationship between regional cerebral blood flow (CBF) and blood oxygenation level dependent (BOLD) changes in the primary visual cortex (V1) at varied visual stimulation frequency has been examined quantitatively using the multislice FAIR technique. A linear correlation in the common activation areas between functional BOLD and CBF maps was observed. This supports the hypothesis that the task-stimulated BOLD changes in microvasculature are correlated with the CBF changes that presumably reflect the degree of neuronal activity. The linear correlation coefficients for intrasubject comparisons are more significant than those for intersubject comparisons. This suggests that using intrasubject comparisons for quantitative studies of neuronal activity related to different task stimuli and task performances should be more reliable than using intersubject comparisons.
使用多层动脉自旋标记（FAIR）技术定量研究了不同视觉刺激频率下初级视觉皮层（V1）的局部脑血流量（CBF）与血氧水平依赖（BOLD）变化之间的关系。在功能性BOLD和CBF图谱的共同激活区域观察到线性相关性。这支持了这样一种假设，即任务刺激引起的微血管BOLD变化与CBF变化相关，而CBF变化可能反映了神经元活动的程度。受试者内比较的线性相关系数比受试者间比较的更显著。这表明，在对与不同任务刺激和任务表现相关的神经元活动进行定量研究时，使用受试者内比较比使用受试者间比较更可靠。
