Sambani C, Trafalis D T, Vessalas G, Politis G, Peristeris P, Nakopoulou L, Giannopoulou J, Michaelidis C, Ayoutantis M, Pantelias G E
Health Physics and Environmental Hygiene Unit, Institute N. T.-R. P., N.C.S.R Demokritos, Athens, Greece.
Cancer Genet Cytogenet. 1998 Oct 15;106(2):180-1. doi: 10.1016/s0165-4608(98)00075-2.
A 65-year-old woman with chronic myelomonocytic leukemia was shown to have trisomy 6 and multiple double minute chromosomes. The patient had no history of prior exposure to any mutagenic or carcinogenic agents. To our knowledge, this is the first report for presence of only these two aberrations. The expression of several oncoproteins and onco-related proteins was detected immunohistochemically in bone marrow cells. Among them, only the bcl-2 oncoprotein was positively stained in 100% of myeloblasts. Although the c-myc oncogene is frequently reported to be overexpressed in myeloid disorders with double minutes and associated with chemotherapy resistance and disease aggressiveness, in our case, the c-myc oncoprotein was not positively expressed. The patient received chemotherapy and complete hematological remission was successfully achieved.
一名65岁的慢性粒单核细胞白血病女性患者被发现有6号染色体三体和多个双微体染色体。该患者既往无任何诱变剂或致癌剂接触史。据我们所知，这是仅存在这两种畸变的首例报告。通过免疫组织化学检测了骨髓细胞中几种癌蛋白和癌相关蛋白的表达。其中，只有bcl-2癌蛋白在100%的成髓细胞中呈阳性染色。尽管经常报道c-myc癌基因在伴有双微体的髓系疾病中过度表达，并与化疗耐药和疾病侵袭性相关，但在我们的病例中，c-myc癌蛋白未呈阳性表达。该患者接受了化疗并成功实现了完全血液学缓解。
