Papadhimitriou S I, Abazis D, Repa C, Papaconstantinou C, Papanastasiou C, Pangalos C, Stamatelou M
Department of Clinical Hematology, Greek Cancer Institute, Athens, Greece.
Cancer Genet Cytogenet. 1995 Nov;85(1):75-7. doi: 10.1016/0165-4608(95)00139-5.
We report a case of chronic myelomonocytic leukemia in which cytogenetic analysis revealed a 47,XY, +1, +der(7)del(7)(q32q36)ins(7;1)(q32;p36.3p22) chromosomal constitution. This abnormal karyotype, which as a whole is new to any myeloid malignancy, points to a possible pathogenetic role for the oncogenes MET and FGR on the derivative chromosome 7, and for the CSF1 and JUN genes flanking the breakpoint on chromosome 1.
我们报告一例慢性粒单核细胞白血病病例，其细胞遗传学分析显示染色体组成为47,XY, +1, +der(7)del(7)(q32q36)ins(7;1)(q32;p36.3p22)。这种异常核型在所有髓系恶性肿瘤中整体上都是新发现的，提示衍生染色体7上的原癌基因MET和FGR，以及染色体1断点两侧的CSF1和JUN基因可能具有致病作用。
