Prah J D
National Health and Environmental Effects Research Laboratory, Human Studies Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 USA.
Environ Health Perspect. 1998 Nov;106(11):739-44. doi: 10.1289/ehp.98106739.
Exposure to low levels of chemicals indoors is often to a mixture of volatile organic compounds (VOCs). It is of interest to determine if the symptomatic and sensory responses can be attributed to a single chemical or to a mixture of chemicals. To determine if sensory or symptomatic responses differ with exposure to single or mixed VOCs, 100 female subjects participated in a 6-hr exposure study. Subjects were exposed to one of six equimolar concentrations equivalent to 24 mg/m3 toluene, control, m-xylene, n-butyl acetate, m-xylene plus n-butyl acetate, a mixture of 21 chemicals including n-butyl acetate and m-xylene, and to the same mixture of chemicals without n-butyl acetate and m-xylene (19 chemicals). The results indicated that there was no difference in reporting of symptoms or sensory responses between the exposures. When the control group was added, some variables, primarily odor intensity and nasal irritation, attained significance.
在室内接触低水平化学物质通常是接触挥发性有机化合物（VOCs）的混合物。确定症状和感官反应是可归因于单一化学物质还是化学物质混合物是很有意义的。为了确定接触单一或混合VOCs时感官或症状反应是否不同，100名女性受试者参与了一项6小时的接触研究。受试者接触六种等摩尔浓度之一，分别相当于24毫克/立方米甲苯、对照组、间二甲苯、乙酸正丁酯、间二甲苯加乙酸正丁酯、包括乙酸正丁酯和间二甲苯在内的21种化学物质的混合物，以及不含乙酸正丁酯和间二甲苯的相同化学物质混合物（19种化学物质）。结果表明，各次接触之间在症状报告或感官反应方面没有差异。当加入对照组时，一些变量，主要是气味强度和鼻刺激，变得显著。
