Otto D A, Hudnell H K, House D E, Mølhave L, Counts W
Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
Arch Environ Health. 1992 Jan-Feb;47(1):23-30. doi: 10.1080/00039896.1992.9935940.
Exposure to a low-level mixture of volatile organic compounds, typical of those found in new buildings, has been reported to impair neurobehavioral function in persons who have experienced sick building syndrome (SBS). Sixty-six healthy young males who had no history of chemical sensitivity were exposed for 2.75 h to a complex mixture of volatile organic compounds at 0 and 25 mg/m3. Even though subjects reported more fatigue and more mental confusion following exposure to volatile organic compounds than to clean air, performance on 13 neurobehavioral tests was not affected. Practice or learning effects were observed if administration of many behavioral tests were repeated. Further studies are needed to clarify the relationship of exposure to volatile organic chemicals, neurobehavioral performance, and subject characteristics, e.g., age, gender, and chemical sensitivity.
据报道，接触低水平挥发性有机化合物混合物（这在新建筑物中很常见）会损害患有“病态建筑综合症”（SBS）的人的神经行为功能。66名无化学物质敏感史的健康年轻男性，在0和25毫克/立方米的浓度下，接触挥发性有机化合物的复杂混合物2.75小时。尽管与接触清洁空气相比，受试者报告称接触挥发性有机化合物后感到更疲劳、精神更混乱，但13项神经行为测试的表现并未受到影响。如果重复进行多项行为测试，则会观察到练习或学习效应。需要进一步研究以阐明接触挥发性有机化学物质、神经行为表现和受试者特征（如年龄、性别和化学敏感性）之间的关系。
