Duggan B D, Dubeau L
Division of Gynecologic Oncology, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90033, USA.
Curr Opin Oncol. 1998 Sep;10(5):439-46. doi: 10.1097/00001622-199809000-00012.
Gynecologic epithelial tumors can be grouped into two major categories depending on whether they are derived embryologically from squamous epithelium of the urogenital sinus or from müllerian ducts. Ovarian carcinomas appear morphologically similar to those arising in müllerian-derived organs, and molecular genetic defects present in tumors from these different sources appear to reflect more their histologic subtypes than their organ of origin. The possibility that ovarian epithelial tumors arise from remnants of müllerian ducts in the vicinity of the ovary therefore merits further investigation. Recent advances in our understanding of the state of clonality of various gynecologic tumors, of the influence of age and ovulatory activity on their genetic characteristics, and of their overall molecular genetic features, provide important clues about their initial underlying mechanisms. Novel strategies based on these advances are being tested for their potential utility in treating and monitoring gynecologic tumors.
妇科上皮性肿瘤可根据其胚胎学来源分为两大类，即源于泌尿生殖窦的鳞状上皮还是苗勒管。卵巢癌在形态学上与起源于苗勒管衍生器官的肿瘤相似，来自这些不同来源肿瘤中的分子遗传学缺陷似乎更多地反映了它们的组织学亚型，而非其起源器官。因此，卵巢上皮性肿瘤起源于卵巢附近苗勒管残余的可能性值得进一步研究。我们对各种妇科肿瘤克隆性状态、年龄和排卵活动对其遗传特征的影响以及其整体分子遗传学特征的认识取得了最新进展，这些进展为其初始潜在机制提供了重要线索。基于这些进展的新策略正在接受测试，以评估其在治疗和监测妇科肿瘤方面的潜在效用。
