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The role of futility judgments in improperly limiting the scope of clinical research.无效性判断在不恰当地限制临床研究范围方面的作用。
J Med Ethics. 1998 Oct;24(5):308-13. doi: 10.1136/jme.24.5.308.
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本文引用的文献

1
Infections and the inflammatory response in acute respiratory distress syndrome.急性呼吸窘迫综合征中的感染与炎症反应
Chest. 1997 May;111(5):1306-21. doi: 10.1378/chest.111.5.1306.
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Prognosis of stroke patients requiring mechanical ventilation in a neurological critical care unit.在神经重症监护病房中需要机械通气的中风患者的预后。
Stroke. 1997 Apr;28(4):711-5. doi: 10.1161/01.str.28.4.711.
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Long-term survival of recipients of allogeneic bone-marrow transplantation after mechanical ventilation.机械通气后同种异体骨髓移植受者的长期生存情况。
Eur J Med Res. 1997 Feb 21;2(2):62-6.
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Bilateral versus single lung transplantation for chronic obstructive pulmonary disease.慢性阻塞性肺疾病的双侧肺移植与单肺移植
J Thorac Cardiovasc Surg. 1997 Mar;113(3):520-7; discussion 528. doi: 10.1016/S0022-5223(97)70365-9.
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Hyperdynamic resuscitation improves survival in patients with life-threatening burns.高动力复苏可提高危及生命的烧伤患者的生存率。
J Burn Care Rehabil. 1997 Jan-Feb;18(1 Pt 1):10-6. doi: 10.1097/00004630-199701000-00002.
6
Paediatric cardiac arrest and resuscitation provided by physician-staffed emergency care units.由配备医生的急救单位提供的儿科心脏骤停及复苏服务。
Acta Anaesthesiol Scand. 1997 Feb;41(2):260-5. doi: 10.1111/j.1399-6576.1997.tb04677.x.
7
Benefit of active compression-decompression cardiopulmonary resuscitation as a prehospital advanced cardiac life support. A randomized multicenter study.主动按压-减压心肺复苏术作为院前高级心脏生命支持的益处:一项随机多中心研究。
Circulation. 1997 Feb 18;95(4):955-61. doi: 10.1161/01.cir.95.4.955.
8
Predicting survival from out-of-hospital cardiac arrest: a multivariate analysis.院外心脏骤停生存情况的预测:一项多变量分析。
Resuscitation. 1997 Feb;34(1):27-34. doi: 10.1016/s0300-9572(96)01031-3.
9
Rhythm changes during resuscitation from ventricular fibrillation in relation to delay until defibrillation, number of shocks delivered and survival.心室颤动复苏期间的节律变化与除颤延迟、电击次数及生存情况的关系
Resuscitation. 1997 Feb;34(1):17-22. doi: 10.1016/s0300-9572(96)01064-7.
10
One-year survival after out-of-hospital cardiac arrest in Bonn city: outcome report according to the 'Utstein style'.波恩市院外心脏骤停后的一年生存率:根据“乌斯坦因模式”的结果报告。
Resuscitation. 1997 Jan;33(3):233-43. doi: 10.1016/s0300-9572(96)01022-2.

无效性判断在不恰当地限制临床研究范围方面的作用。

The role of futility judgments in improperly limiting the scope of clinical research.

作者信息

Harper W

机构信息

University of Alabama, USA.

出版信息

J Med Ethics. 1998 Oct;24(5):308-13. doi: 10.1136/jme.24.5.308.

DOI:10.1136/jme.24.5.308
PMID:9800585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1377603/
Abstract

In medical research, the gathering and presenting of data can be limited in accordance with the futility judgments of the researchers. In that case, research results falling below the threshold of what the researchers deem beneficial would not to be reported in detail. As a result, the reported information would tend to be useful only to those who share the valuational assumptions of the researchers. Should this practice become entrenched, it would reduce public confidence in the medical establishment, aggravate factionalism within the research community, and unduly influence treatment decisions. I suggest alternative frameworks for measuring survival outcomes.

摘要

在医学研究中,数据的收集和呈现可能会根据研究人员的无效性判断而受到限制。在这种情况下,低于研究人员认为有益阈值的研究结果将不会被详细报告。因此,所报告的信息可能仅对那些与研究人员有相同价值假设的人有用。如果这种做法变得根深蒂固,将会降低公众对医疗机构的信心,加剧研究界的派系之争,并对治疗决策产生不当影响。我建议采用其他框架来衡量生存结果。