Capo C, Iorgulescu I, Mutillod M, Mege J L, Raoult D
Unité des Rickettsies, Université de la Méditerranée, CNRS UPRESA 6020, Faculté de Médecine, 13385 Marseille Cedex 05, France.
Clin Diagn Lab Immunol. 1998 Nov;5(6):814-6. doi: 10.1128/CDLI.5.6.814-816.1998.
A detailed analysis of the humoral response to Coxiella burnetii may provide insight into the pathogenesis of Q fever, a zoonosis caused by C. burnetii. The subclasses of C. burnetii-specific antibodies were determined by immunofluorescence in 20 patients with acute Q fever and 20 patients with chronic Q fever. Although immunoglobulin G1 (IgG1) and IgG3 antibodies were found in acute and chronic Q fever, neither IgG2 nor IgG4 was detected. The detection of IgG1 and IgG3 antibodies was not due to an increase of the IgG1 and IgG3 subclasses. Moreover, IgG1 and IgG3 antibodies were not correlated, suggesting that they may play different roles in Q fever.
对伯纳特立克次体体液免疫反应的详细分析，可能有助于深入了解由伯纳特立克次体引起的人畜共患病——Q热的发病机制。通过免疫荧光法测定了20例急性Q热患者和20例慢性Q热患者体内伯纳特立克次体特异性抗体的亚类。虽然在急性和慢性Q热患者中均发现了免疫球蛋白G1（IgG1）和IgG3抗体，但未检测到IgG2和IgG4。IgG1和IgG3抗体的检测并非由于IgG1和IgG3亚类的增加。此外，IgG1和IgG3抗体之间无相关性，这表明它们在Q热中可能发挥不同作用。
