Grammer L C, Shaughnessy M A, Kabalin C S, Yarnold P R, Malo J L, Cartier A
Department of Medicine, Center of Northwestern Memorial Hospital, Chicago, Illinois, USA.
Allergy Asthma Proc. 1998 Sep-Oct;19(5):301-5. doi: 10.2500/108854198778557755.
This pilot study investigated serum levels of cytokines and soluble receptors during five positive and five negative isocyanate inhalational challenges. Serum was obtained from 10 individuals with symptoms compatible with isocyanate asthma before isocyanate challenge and the day following their maximal change in pulmonary function after isocyanate challenge. Serum levels of interleukin 1 beta, interleukin 3, interleukin 4, soluble interleukin 2 receptor, and soluble intercellular adhesion molecule 1 were measured and compared. Interleukin 1 beta, interleukin 3, and interleukin 4 were not detected. The mean soluble interleukin 2 receptor and soluble intercellular adhesion molecule 1 levels were not statistically different before and after challenge or between groups. In summary, the cytokines studied are not detectable in peripheral blood during isocyanate inhalation challenge; soluble interleukin 2 receptor and soluble intercellular adhesion molecule 1 are both detectable but do not change significantly after a positive isocyanate challenge.
这项初步研究调查了在五次异氰酸酯吸入激发试验阳性和五次阴性过程中细胞因子和可溶性受体的血清水平。在异氰酸酯激发试验前以及在异氰酸酯激发试验后肺功能出现最大变化的次日，从10名有与异氰酸酯哮喘相符症状的个体采集血清。检测并比较了白细胞介素1β、白细胞介素3、白细胞介素4、可溶性白细胞介素2受体和可溶性细胞间黏附分子1的血清水平。未检测到白细胞介素1β、白细胞介素3和白细胞介素4。激发试验前后以及各组之间，可溶性白细胞介素2受体和可溶性细胞间黏附分子1的平均水平无统计学差异。总之，在异氰酸酯吸入激发试验期间外周血中无法检测到所研究的细胞因子；可溶性白细胞介素2受体和可溶性细胞间黏附分子1均可检测到，但在异氰酸酯激发试验阳性后无显著变化。
