Yeste D, del Río L, Gussinyé M, Carrascosa A
Hospital Materno-Infantil Vall d'Hebron, Departamento de Pediatría, Universidad Autónoma de Barcelona.
An Esp Pediatr. 1998 Sep;49(3):248-52.
A cross-sectional study of bone mineral density was conducted in a normal population of children with ages ranging from the neonatal period to 4 years with the aim of establishing normal bone mineral density (BMD) patterns.
Bone mineral content density was measured by dual-energy X-ray absorptiometry at the level of the lumbar spine (L2-L4) in 147 normal children (69 boys, 78 girls, age range: 15 days to 4 years) randomly selected from the urban area of Barcelona.
Weight, length and height were in the normal age distribution. Bone mineral content values were corrected by the vertebral surface area scanned and expressed as bone mineral density values (grams of hydroxyapatite/cm2). Bone mineral density values increased progressively from birth to 4 years and values were similar in both sexes. A statistically significant correlation was found between BMD values and age (r = 0.82, p < 0.001), weight (r = 0.87, p < 0.001) and length or height (r = 0.79, p < 0.001). Lumbar bone mineral density values increased annually, but the periods of higher increase were observed during the first 2 years of life. Bone mineral density values showed a similar pattern to height growth velocity.
We report normative data for bone mineral density at the lumbar spine in our normally-growing pediatric population from the neonatal period to 4 years. These data provide a tool for the study and follow-up of pediatric populations at risk for low bone mineralization during early childhood.
对年龄从新生儿期到4岁的正常儿童群体进行骨密度横断面研究，目的是建立正常的骨密度（BMD）模式。
对从巴塞罗那市区随机选取的147名正常儿童（69名男孩，78名女孩，年龄范围：15天至4岁），采用双能X线吸收法测量腰椎（L2-L4）水平的骨矿物质含量密度。
体重、身长和身高均处于正常年龄分布。骨矿物质含量值通过扫描的椎体表面积进行校正，并表示为骨密度值（羟基磷灰石克数/cm²）。骨密度值从出生到4岁逐渐增加，且两性之间的值相似。发现骨密度值与年龄（r = 0.82，p < 0.001）、体重（r = 0.87，p < 0.001）以及身长或身高（r = 0.79，p < 0.001）之间存在统计学显著相关性。腰椎骨密度值每年增加，但在生命的前2年观察到增加幅度较大的时期。骨密度值显示出与身高生长速度相似模式。
我们报告了从新生儿期到4岁正常生长的儿科人群腰椎骨密度的规范数据。这些数据为研究和随访幼儿期骨矿化低风险的儿科人群提供了一种工具。
