Loening W E, Coovadia H M
Lancet. 1983 Aug 6;2(8345):324-6. doi: 10.1016/s0140-6736(83)90299-4.
Measles vaccination is unsatisfactory in infants less than 8 months old. To find out what proportion of children with measles in the developing world fall within this age range, a survey was conducted in Natal/Kwa Zulu. Data were collected from urban (community-based survey, infectious diseases hospital data, referral centre date), peri-urban (regional hospital and clinics), and rural (3 local hospitals and their peripheral clinics) populations. There was a positive association between population density and the percentage of measles cases aged 8 months or less. 20-45% of measles patients in urban areas, 15% in the peri-urban zone, and 6-12% in rural Kwa Zulu had the disease at or below 8 months of age. The mortality rate for measles in this age group at the referral centre was 26%. There is an urgent need for effective methods of immunizing the very young against measles in high-density regions of developing countries.
对于8个月以下的婴儿，麻疹疫苗接种效果并不理想。为了弄清楚发展中世界患麻疹的儿童中处于这个年龄范围的比例，在纳塔尔/夸祖鲁进行了一项调查。数据收集自城市（基于社区的调查、传染病医院数据、转诊中心数据）、城郊（地区医院和诊所）以及农村（3家当地医院及其周边诊所）人群。人口密度与8个月及以下麻疹病例的百分比之间存在正相关。城市地区20% - 45%的麻疹患者、城郊地区15%的麻疹患者以及夸祖鲁农村地区6% - 12%的麻疹患者在8个月及以下时患病。转诊中心该年龄组的麻疹死亡率为26%。在发展中国家的高密度地区，迫切需要有效的方法为幼儿接种麻疹疫苗。
