Sabin C A, Mocroft A, Bofill M, Janossy G, Lee C A, Johnson M, Phillips A N
Department of Primary Care and Population Sciences, Royal Free Hospital and School of Medicine, London, United Kingdom.
J Infect Dis. 1998 Oct;178(4):1166-9. doi: 10.1086/515676.
All patients seen at the Royal Free Hospital, London, who had at least one CD4 T lymphocyte count of < 5 cells/mm3 (n = 166) were prospectively followed to assess changes in their total T lymphocyte and CD8 T lymphocyte counts over time. While overall there were no clear trends towards a drop or increase in either count, persons who died during the study experienced a rapid drop in both CD8 T lymphocyte and total T lymphocyte levels in the months preceding death. Multivariate Cox proportional hazards models revealed that both the total T lymphocyte count and CD8 T lymphocyte count provided important prognostic information for survival. Despite almost a complete absence of CD4 T lymphocytes, lymphocyte subset monitoring is useful in identifying decreasing CD8 T lymphocyte levels that predict short-term prognosis.
在伦敦皇家自由医院就诊的所有患者，若其CD4 T淋巴细胞计数至少有一次低于5个细胞/立方毫米（n = 166），则对其进行前瞻性随访，以评估其总T淋巴细胞和CD8 T淋巴细胞计数随时间的变化。总体而言，这两种计数均无明显的下降或上升趋势，但在研究期间死亡的患者在死亡前几个月其CD8 T淋巴细胞和总T淋巴细胞水平均迅速下降。多变量Cox比例风险模型显示，总T淋巴细胞计数和CD8 T淋巴细胞计数均为生存提供了重要的预后信息。尽管几乎完全缺乏CD4 T淋巴细胞，但淋巴细胞亚群监测对于识别可预测短期预后的CD8 T淋巴细胞水平下降是有用的。
