Schmuñis G A, Szarfman A, Coarasa L, Vainstok C
Am J Trop Med Hyg. 1978 May;27(3):473-7. doi: 10.4269/ajtmh.1978.27.473.
Immunoglobulin M, G, and A concentrations were studied by radial immunodiffusion technique in 16 individuals (two were 16 and 14 yr of age, respectively, while the remaining 14 uere 15 yr of age or less) with acute Trypanosoma cruzi infection. Serum samples were obtained from these patients beginning with the onset of symptoms and continuing until several months after treatment with nifurtimox was completed. Soon after infection the concentration of IgM was higher than the average found in healthy children. Some of the samples also had higher values than those found in children with other acute infections. At this time isolated increases in IgG and/or IgA concentrations were also found in T. cruzi-infected patients. Immunoglobulin concentrations had usually returned to normal when treatment with nifurtimox was completed, both in the patients with negative serology and in those who remained positive. However, some of the sera showed isolated higher IgM, IgG, and/or IgA values than those found in healthy controls.
采用放射免疫扩散技术，对16例急性克氏锥虫感染患者（其中2例分别为16岁和14岁，其余14例为15岁及以下）的免疫球蛋白M、G和A浓度进行了研究。从这些患者出现症状开始采集血清样本，并持续至硝呋替莫治疗结束后的数月。感染后不久，IgM浓度高于健康儿童的平均水平。部分样本的值也高于其他急性感染儿童的值。此时，克氏锥虫感染患者还出现了IgG和/或IgA浓度的单独升高。在接受硝呋替莫治疗结束时，无论是血清学检查呈阴性的患者还是仍呈阳性的患者，免疫球蛋白浓度通常都已恢复正常。然而，部分血清的IgM、IgG和/或IgA值单独高于健康对照者。
