Chen M Y, Ott D J, Casolo B J, Moghazy K M, Koufman J A
Department of Radiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
Otolaryngol Head Neck Surg. 1998 Nov;119(5):460-2.
The cause of laryngeal and pharyngeal carcinomas is likely multifactorial. Smoking is an important factor, but mucosal damage from gastroesophageal reflux may also contribute. The purpose of this study was to determine whether gastroesophageal reflux is more common in patients with laryngeal or pharyngeal carcinomas than in those without these malignancies. Over an 8-year period, we correlated the results of clinical and radiographic examinations of the pharynx and esophagus to pH monitoring results in 798 patients with a variety of upper aerodigestive tract symptoms and who underwent both pH monitoring and barium esophagography. In this group, 63 patients (52 men, 11 women) had laryngeal or pharyngeal carcinomas, and 735 patients (319 men, 416 women) had neither malignancy. Abnormal pH findings were defined as a total percentage of esophageal acid exposure time of 6% or more as determined with the esophageal probe, or any reflux event detected with the pharyngeal probe. Thirty-four of 63 patients with carcinomas (54%) had abnormal pH-monitoring results: Esophageal acid exposure was abnormal in 10 patients, pharyngeal acid exposure was abnormal in 7 patients, and acid exposure was abnormal in both areas in 17 patients. Of the 735 patients without malignancies, 365 (50%) had abnormal pH-monitoring results (p > 0.05). In this population of patients, abnormal results of pH monitoring were common, occurring in 399 (50%) of 798 patients, but no significant difference was found between results in those with and without laryngeal or pharyngeal carcinomas. Therefore, our study found that gastroesophageal reflux as shown by pH monitoring was not more common in patients with these malignancies.
喉癌和咽癌的病因可能是多因素的。吸烟是一个重要因素，但胃食管反流造成的黏膜损伤也可能起作用。本研究的目的是确定胃食管反流在喉癌或咽癌患者中是否比在无这些恶性肿瘤的患者中更常见。在8年期间，我们将798例有各种上消化道症状且接受了pH监测和食管钡餐造影的患者的咽和食管的临床及影像学检查结果与pH监测结果进行了关联。在该组中，63例患者（52例男性，11例女性）患有喉癌或咽癌，735例患者（319例男性，416例女性）无恶性肿瘤。pH异常结果定义为食管探头测定的食管酸暴露时间总百分比达6%或更高，或咽探头检测到任何反流事件。63例癌症患者中有34例（54%）pH监测结果异常：10例患者食管酸暴露异常，7例患者咽酸暴露异常，17例患者两个部位酸暴露均异常。在735例无恶性肿瘤的患者中，365例（50%）pH监测结果异常（p>0.05）。在这群患者中，pH监测异常结果很常见，798例患者中有399例（50%）出现异常，但在有和无喉癌或咽癌的患者结果之间未发现显著差异。因此，我们的研究发现，pH监测显示的胃食管反流在这些恶性肿瘤患者中并不更常见。
