乳腺癌中的人类白细胞抗原（HLA）
Human leucocytic antigens (HLA) in breast cancer.
作者信息
Biswal B M, Kumar R, Julka P K, Sharma U, Vaidya M C
机构信息
Radiotherapy Dept, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
出版信息
Indian J Med Sci. 1998 May;52(5):177-83.
HLA frequencies of fifty (50) female breast cancer patients were compared with 200 age matched female controls. A total of 20 HLA-A locus, 35 HLA-B locus and 8 HLA-C locus antigens were studied. The HLA-A2, A11, Aw19 and A30; HLA-B8, B14 and HLA Cw6 were found significantly higher than the controls. The HLA-A11, HLA-Aw19 and HLA-B8 were found protective whereas, HLA-A2, HLA-B14 and HLA-Cw6 were a risk for breast cancer. The prective antigens' probable involvement through immunogenic mechanism in breast cancer is emphasized in this article.
对50名女性乳腺癌患者的HLA频率与200名年龄匹配的女性对照进行了比较。共研究了20种HLA - A位点、35种HLA - B位点和8种HLA - C位点抗原。发现HLA - A2、A11、Aw19和A30；HLA - B8、B14和HLA Cw6显著高于对照组。发现HLA - A11、HLA - Aw19和HLA - B8具有保护作用，而HLA - A2、HLA - B14和HLA - Cw6是乳腺癌的危险因素。本文强调了保护性抗原可能通过免疫原性机制参与乳腺癌的发生。
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