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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol Suppl. 1998 Nov;25:S12-5. doi: 10.1111/j.1440-1681.1998.tb02294.x.

A brief account of the history of developmental biology at the Howard Florey Institute, as well as in a wider general context, is presented and some of the results of developmental studies performed at the Institute over the past 7 years are discussed. 2. In the foetal rat, parathyroid hormone rather than parathyroid hormone-related protein is produced by the parathyroid anlage. This contrasts with results reported by others for the sheep. 3. The control of imprinting of H19 and insulin-like growth factor-II has been studied in the mouse using gene knockout of the coding region of the H19 gene. Bi-allelic expression of H19 in some liver and gut cells was observed. 4. Gene knockout of the homeobox gene Cdx2 produced dramatic effects. Homozygous embryos did not implant in the uterus. Heterozygotes exhibited homeosis involving the gut and skeleton. Animals developed intestinal tumours within a few weeks of birth.

简要介绍了霍华德·弗洛里研究所发育生物学的历史，以及更广泛的背景，并讨论了该研究所在过去7年中进行的一些发育研究结果。2. 在胎鼠中，甲状旁腺原基产生的是甲状旁腺激素而非甲状旁腺激素相关蛋白。这与其他关于绵羊的报道结果形成对比。3. 利用H19基因编码区的基因敲除技术，在小鼠中研究了H19和胰岛素样生长因子-II的印记控制。在一些肝脏和肠道细胞中观察到H19的双等位基因表达。4. 同源盒基因Cdx2的基因敲除产生了显著影响。纯合子胚胎无法在子宫内着床。杂合子表现出涉及肠道和骨骼的同源异形现象。动物在出生后几周内就发展出肠道肿瘤。

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol Suppl. 1998 Nov;25:S12-5. doi: 10.1111/j.1440-1681.1998.tb02294.x.

A brief account of the history of developmental biology at the Howard Florey Institute, as well as in a wider general context, is presented and some of the results of developmental studies performed at the Institute over the past 7 years are discussed. 2. In the foetal rat, parathyroid hormone rather than parathyroid hormone-related protein is produced by the parathyroid anlage. This contrasts with results reported by others for the sheep. 3. The control of imprinting of H19 and insulin-like growth factor-II has been studied in the mouse using gene knockout of the coding region of the H19 gene. Bi-allelic expression of H19 in some liver and gut cells was observed. 4. Gene knockout of the homeobox gene Cdx2 produced dramatic effects. Homozygous embryos did not implant in the uterus. Heterozygotes exhibited homeosis involving the gut and skeleton. Animals developed intestinal tumours within a few weeks of birth.

简要介绍了霍华德·弗洛里研究所发育生物学的历史，以及更广泛的背景，并讨论了该研究所在过去7年中进行的一些发育研究结果。2. 在胎鼠中，甲状旁腺原基产生的是甲状旁腺激素而非甲状旁腺激素相关蛋白。这与其他关于绵羊的报道结果形成对比。3. 利用H19基因编码区的基因敲除技术，在小鼠中研究了H19和胰岛素样生长因子-II的印记控制。在一些肝脏和肠道细胞中观察到H19的双等位基因表达。4. 同源盒基因Cdx2的基因敲除产生了显著影响。纯合子胚胎无法在子宫内着床。杂合子表现出涉及肠道和骨骼的同源异形现象。动物在出生后几周内就发展出肠道肿瘤。