Ellerbeck K A, Smith M L, Holden E W, McMenamin S C, Badawi M A, Brenner J I, Kan J S, Hyman S L
Children's Mercy Hospital, Section of Developmental and Behavioral Sciences, Kansas City, MO 64108, USA.
J Dev Behav Pediatr. 1998 Oct;19(5):335-41. doi: 10.1097/00004703-199810000-00003.
We investigated the prevalence of neurological abnormalities and learning problems in a population cohort of children with dextro-transposition of the great arteries (d-TGA) born between January 1, 1981 and July 1, 1990. Fifty-seven of the 60 survivors and 35 siblings in the control group underwent neurodevelopmental assessments. As compared with population norms, children with d-TGA were more likely to have abnormal neurological examination findings, learning disabilities, and behavioral disorders. There was no significant difference in IQ or frequency of abnormal neurological examination results between children undergoing atrial as compared with arterial switch procedures. Compared with their siblings, the children with d-TGA had more neurological findings and learning disabilities. The siblings of children with d-TGA had more learning problems than expected. The findings suggest that ongoing surveillance is indicated for children surviving d-TGA. Furthermore, a familial tendency for learning differences should to be taken into consideration when neurodevelopmental outcomes of various perioperative parameters are examined.
我们调查了1981年1月1日至1990年7月1日出生的大动脉右位转位（d-TGA）儿童人群队列中的神经功能异常和学习问题患病率。60名幸存者中的57名以及对照组中的35名同胞接受了神经发育评估。与总体标准相比，d-TGA儿童更有可能出现神经检查结果异常、学习障碍和行为障碍。接受心房转位手术与动脉调转手术的儿童在智商或神经检查异常结果频率方面没有显著差异。与他们的同胞相比，d-TGA儿童有更多的神经学表现和学习障碍。d-TGA儿童的同胞有比预期更多的学习问题。这些发现表明，对于d-TGA存活儿童需要进行持续监测。此外，在检查各种围手术期参数的神经发育结果时，应考虑到学习差异的家族倾向。
