Gajkowska B, Viron A
Laboratory of the Ultrastructure of Nervous System, Polish Academy of Sciences, Warszawa, Poland.
Folia Neuropathol. 1996;34(4):173-7.
Endothelin is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. To examine the potential role of endothelin as a neuropeptide, we studied its distribution in the neurosecretory system. Endothelin-like immunoreactivity (EN-IR) has been demonstrated by an immunogold method in the paraventricular and supraoptic nuclear neurons and their terminals in the posterior pituitary of the rat. ET-IR was enhanced after ischemia suggesting its modulatory role in neurosecretory functions.
内皮素是一种由内皮细胞产生的非常强大的内源性血管收缩物质。为了研究内皮素作为一种神经肽的潜在作用，我们研究了它在神经分泌系统中的分布。通过免疫金法已在大鼠垂体后叶的室旁核和视上核神经元及其终末中证实了内皮素样免疫反应性（EN-IR）。缺血后ET-IR增强，提示其在神经分泌功能中的调节作用。
