Li S, Guo Y, Mo Y
Department of Epidemiology, Hubei Medical University, Wuhan.
Zhonghua Yu Fang Yi Xue Za Zhi. 1997 May;31(3):137-9.
Capture of rats by digging their cavities, identification of rat strains, sex and age, examination of their skin cut or damage, and detection of antigen and antibody of epidemic hemorrhagic fever virus (EHFV) were conducted in epidemic areas of epidemic hemorrhagic fever (EHF) in Jinaghan Plain, Hubei Province, to study prevalence of EHFV infection in rats. Results showed that Apodemus agarius and Rattus norvegius accounted for 69.7% and 23.6% of the total rats captured, respectively, their infection rates of EHFV were 21.8% and 30.9%, respectively. Infection rate of EHFV was significantly higher in adult rats than in sub-adult and young ones, with prevalence of 40.8%, 17.0% and 12.4%, respectively. Infection rate of EHFV was 45.9% in rats with skin cut, significantly higher than in those without it (13.9%). There was an obvious litter-clustering phenomenon in infected rats, but their litters distributed in space randomly. Serotyping of infected rats showed that Apodemus agarius mainly was in a wild rat pattern, Rattus norvegius in a domestic rat pattern, and a small number of rats were in undefined patterns. It indicated that Jinaghan Plain was a mixed epidemic area of EHF with domestic and wild rat patterns and with Apodemus agarius and Rattus norvegius as main reservoir host, and age, skin cut, and close contact with them were important factors contributing to transmit it.
在湖北省江汉平原流行性出血热（EHF）疫区，通过挖洞捕鼠，对鼠种、性别和年龄进行鉴定，检查其皮肤破损情况，并检测流行性出血热病毒（EHFV）抗原和抗体，以研究鼠类中EHFV感染的流行情况。结果显示，黑线姬鼠和褐家鼠分别占捕获鼠总数的69.7%和23.6%，它们的EHFV感染率分别为21.8%和30.9%。EHFV在成年鼠中的感染率显著高于亚成年鼠和幼鼠，分别为40.8%、17.0%和12.4%。有皮肤破损的鼠EHFV感染率为45.9%，显著高于无皮肤破损的鼠（13.9%）。感染鼠存在明显的窝集现象，但它们的窝在空间上随机分布。感染鼠的血清型分析表明，黑线姬鼠主要为野鼠型，褐家鼠主要为家鼠型，少数鼠为未定型。这表明江汉平原是一个家鼠型与野鼠型混合的EHF疫区，以黑线姬鼠和褐家鼠为主要储存宿主，年龄、皮肤破损以及与它们的密切接触是传播该病的重要因素。
