Crouch E C
Department of Pathology, Barnes-Jewish Hospital at Washington University Medical Center, 216 S. Kingshighway, St. Louis, MO 63110, USA.
Biochim Biophys Acta. 1998 Nov 19;1408(2-3):278-89. doi: 10.1016/s0925-4439(98)00073-8.
Surfactant protein D (SP-D) is a member of the family of collagenous host defense lectins, designated collectins. There is increasing evidence that SP-D, like SP-A, is an important component of the innate immune response to microbial challenge, and that it may participate in other aspects of immune and inflammatory regulation within the lung. SP-D binds to glycoconjugates and/or lipid moieties expressed by a wide variety of microorganisms and certain other organic particles, in vitro. Although binding may facilitate microbial clearance through aggregation or other direct effects on the organism, SP-D also has the capacity to modulate leukocyte function, and in some circumstances, to enhance their killing of microorganisms.
表面活性蛋白D（SP-D）是胶原性宿主防御凝集素家族（即collectins）的成员之一。越来越多的证据表明，与表面活性蛋白A（SP-A）一样，SP-D是对微生物攻击的固有免疫反应的重要组成部分，并且它可能参与肺内免疫和炎症调节的其他方面。在体外，SP-D可与多种微生物和某些其他有机颗粒表达的糖缀合物和/或脂质部分结合。虽然结合可能通过聚集或对生物体的其他直接作用促进微生物清除，但SP-D也有调节白细胞功能的能力，并且在某些情况下，能增强白细胞对微生物的杀伤作用。
