阿尔茨海默病及其他痴呆症中认知和功能障碍与抑郁特征的关系。

Relationship of cognitive and functional impairment to depressive features in Alzheimer's disease and other dementias.

作者信息

Payne J L, Lyketsos C G, Steele C, Baker L, Galik E, Kopunek S, Steinberg M, Warren A

机构信息

Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

出版信息

J Neuropsychiatry Clin Neurosci. 1998 Fall;10(4):440-7. doi: 10.1176/jnp.10.4.440.

DOI:10.1176/jnp.10.4.440

PMID:9813790

Abstract

Patients with clinical diagnoses of Alzheimer's disease, vascular dementia, or undifferentiated dementia were rated on standardized measures of depression, cognitive impairment, and functional impairment. Logistic regression was used to evaluate the relationship between functional or cognitive impairment, as well as their interaction, and depressive features in each group. This analysis revealed notable differences by type of dementia. The results imply that the mechanisms underlying depression in Alzheimer's disease may be different from those in vascular and other types of dementia. These results also provide indicators to the clinician for further evaluation of depression in different dementia subtypes.

摘要

对临床诊断为阿尔茨海默病、血管性痴呆或未分化痴呆的患者进行抑郁、认知障碍和功能障碍的标准化测量。采用逻辑回归来评估每组中功能或认知障碍及其相互作用与抑郁特征之间的关系。该分析揭示了不同类型痴呆之间的显著差异。结果表明，阿尔茨海默病中抑郁的潜在机制可能与血管性痴呆和其他类型痴呆不同。这些结果也为临床医生进一步评估不同痴呆亚型中的抑郁提供了指标。