Wu Z, Zhang G, Wang X, Song G, Wang H, Long M, Cai S, Wu Y
Bioengineering Research Institute, Chongqing University.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 1997 Jun;14(2):111-4.
Using micropipette aspiration technique, the authors investigated the viscoelastic properties of human fetal hepatocytes (HFH) and hepatocellular carcinoma (HCC) cells. And further, the effects of two cytoskeleton interferents, cytochalasin D and colchicine on the viscoelastic properties of HFHs were investigated. The results showed: the elastic coefficients K1 and K2 of HCC cells were significantly higher than those of HFHs; the action of cytochalasin D led to an obvious decrease in elastic coefficients K1, K2 as well as the viscous coefficient mu of HFHs; under the action of colchicine, the K1 value of HFHs increased while the K2 and mu values decreased obviously or tended to decrease. A brief discussion was presented about these results.
作者运用微量吸管抽吸技术研究了人胎儿肝细胞（HFH）和肝细胞癌（HCC）细胞的粘弹性特性。此外，还研究了两种细胞骨架干扰剂细胞松弛素D和秋水仙碱对HFH粘弹性特性的影响。结果显示：HCC细胞的弹性系数K1和K2显著高于HFH；细胞松弛素D的作用导致HFH的弹性系数K1、K2以及粘性系数μ明显降低；在秋水仙碱作用下，HFH的K1值升高，而K2和μ值明显降低或趋于降低。对这些结果进行了简要讨论。
