Chien S, Sung K L
Biophys J. 1984 Sep;46(3):383-6. doi: 10.1016/S0006-3495(84)84034-5.
The effect of colchicine (15-60 micrograms/ml) on the viscoelastic properties of human neutrophils was studied by the micropipette technique. The small deformation of the neutrophil in response to a step aspiration pressure was analyzed by using a three-element model in which an elastic element, K1, is in parallel with a Maxwell element composed of another elastic element, K2, in series with a viscous element, mu. Colchicine treatment of neutrophils caused decreases in K2 and mu without affecting K1. The results indicate that the integrity of the microtubules plays a significant role in providing the viscoelastic resistance (as represented by the Maxwell element in the model) of neutrophils to deforming stress.
采用微量移液管技术研究了秋水仙碱（15 - 60微克/毫升）对人中性粒细胞粘弹性特性的影响。通过使用一个三元模型分析中性粒细胞对阶跃抽吸压力的小变形，该模型中一个弹性元件K1与一个麦克斯韦元件并联，麦克斯韦元件由另一个弹性元件K2与一个粘性元件μ串联组成。用秋水仙碱处理中性粒细胞会导致K2和μ降低，而不影响K1。结果表明，微管的完整性在为中性粒细胞提供对变形应力的粘弹性阻力（如模型中的麦克斯韦元件所示）方面起着重要作用。
