萘普生对华法林在人血清中蛋白结合的影响。
Effect of naproxen on protein binding of warfarin in human serum.
作者信息
Yacobi A, Levy G
出版信息
Res Commun Chem Pathol Pharmacol. 1976 Oct;15(2):369-72.
PMID:981793
Abstract
The effect of the non-steroidal anti-inflammatory agent naproxen on the protein binding of racemic warfarin in pooled human serum was determined by equilibrium dialysis. The free fraction of warfarin in serum increased practically linearly with increasing naproxen concentration. At the highest naproxen concentration tested (400 mcg/ml), the warfarin free fraction was 74% larger than the control free fraction value.
摘要
通过平衡透析法测定了非甾体抗炎药萘普生对消旋华法林在混合人血清中蛋白结合的影响。血清中华法林的游离分数实际上随萘普生浓度的增加呈线性增加。在测试的最高萘普生浓度（400微克/毫升）下，华法林的游离分数比对照游离分数值大74%。
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