Khan Z K, Chowdhary L, Gyanchandani A, Goswami M, Farooqui N, Ranade S A
Medical Mycology Division, Central Drug Research Institute, Lucknow, India.
Biochem Mol Biol Int. 1998 Oct;46(3):537-48. doi: 10.1080/15216549800204062.
Invasive pulmonary aspergillosis in immunocompromised patients (ICP) is the second most frequent opportunistic fungal infection. The causative organism includes 16 species of Aspergillus, of which A. fumigatus dominates the ubiquitous incidence of invasive or allergic broncho-pulmonary aspergillosis (ABPA). The definitive diagnosis of invasive aspergillosis is difficult. We have analyzed 24 strains of A. fumigatus recovered from ICP using the RAPD technique. The profiles generated with the 20 primers tested were mostly unique. These results may have a profound impact on the management of aspergillosis, especially in the ICP.
免疫功能低下患者（ICP）的侵袭性肺曲霉病是第二常见的机会性真菌感染。致病微生物包括16种曲霉，其中烟曲霉在侵袭性或过敏性支气管肺曲霉病（ABPA）的普遍发病率中占主导地位。侵袭性曲霉病的确诊很困难。我们使用随机扩增多态性DNA（RAPD）技术分析了从ICP患者中分离出的24株烟曲霉。用20种测试引物产生的图谱大多是独特的。这些结果可能对曲霉病的治疗产生深远影响，尤其是在ICP患者中。
