Halpern M J, Dahlgren A L, Laakso I, Seppänen-Laakso T, Dahlgren J, McAnulty P A
Superior Institute for Health Sciences, Lisbon, Portugal.
J Int Med Res. 1998 Aug-Sep;26(4):171-80. doi: 10.1177/030006059802600401.
An extract from red-wine grape fermentation, ANOX has been developed as a source of red-wine polyphenols, which are thought to inhibit several of the pathogenic pathways that lead to cardiovascular disease. New data indicate that this extract has a significantly greater effect than either red wine or red-wine powder on the inhibition of platelet aggregation in vitro. Based on this data, about 300 - 500 mg of the extract is equivalent to the daily dose of red-wine polyphenols that appears to protect against cardiovascular disease. The possible synergistic effect of red-wine polyphenols with vitamin C, their vasorelaxing activity and their possible role in preventing over-crosslinking of connective tissues (premature ageing) are considered. The extract contains standardized amounts of the whole spectrum of polyphenolic compounds found in red wine and may provide a valuable reference substance in clinical investigations of the physiological actions of plant polyphenols; its potential use in functional nutrition and preventive medicine is also discussed.
ANOX是一种从红葡萄酒葡萄发酵中提取的物质，作为红葡萄酒多酚的来源而开发，红葡萄酒多酚被认为可抑制多种导致心血管疾病的致病途径。新数据表明，这种提取物在体外抑制血小板聚集方面的效果比红葡萄酒或红葡萄酒粉显著更强。基于这些数据，约300 - 500毫克的提取物相当于似乎能预防心血管疾病的红葡萄酒多酚的日剂量。研究还考虑了红葡萄酒多酚与维生素C可能的协同作用、它们的血管舒张活性以及它们在防止结缔组织过度交联（过早衰老）中可能发挥的作用。该提取物含有红葡萄酒中发现的全谱多酚化合物的标准化含量，可能为植物多酚生理作用的临床研究提供有价值的参考物质；还讨论了其在功能营养和预防医学中的潜在用途。
