Armentia A, Lombardero M, Callejo A, Martín Santos J M, Gil F J, Vega J, Arranz M L, Martínez C
Servicios de Alergia y Bioquímica del Hospital Rio Hortega, Valladolid, Spain.
J Allergy Clin Immunol. 1998 Nov;102(5):831-4. doi: 10.1016/s0091-6749(98)70024-7.
No cases of occupational asthma caused by the inhalation of antigens from Anisakis simplex have been published.
The purpose of this study was to evaluate the possibility that A simplex can play a role in the asthma experienced by 2 workers when handling fish and fish flour.
Skin prick and bronchial challenge tests with A simplex were performed. We also carried out measurements of specific IgE to A simplex and immunoblotting.
Both patients had strong positive skin test responses, challenge test responses, and specific IgE to A simplex. Immunoblotting showed that both patients also had IgE against several bands in the fish flour extract, suggesting contamination by Anisakis allergens.
These 2 patients provide evidence for occupational asthma caused by A simplex, based on in vivo and in vitro tests for Anisakis-specific IgE.
尚无因吸入简单异尖线虫抗原导致职业性哮喘的病例报道。
本研究旨在评估简单异尖线虫在两名工人处理鱼类和鱼粉时所患哮喘中发挥作用的可能性。
对简单异尖线虫进行皮肤点刺试验和支气管激发试验。我们还检测了针对简单异尖线虫的特异性IgE并进行免疫印迹分析。
两名患者对简单异尖线虫的皮肤试验反应、激发试验反应及特异性IgE均呈强阳性。免疫印迹分析显示，两名患者对鱼粉提取物中的多条条带也有IgE反应，提示存在异尖线虫过敏原污染。
基于针对异尖线虫特异性IgE的体内和体外试验，这两名患者为简单异尖线虫所致职业性哮喘提供了证据。
