Audicana María Teresa
Department of Allergy and Clinical Immunology, University Hospital of Araba (HUA), OSI ARABA, Basque Country, 01009 Vitoria-Gasteiz, Spain.
Pathogens. 2022 Mar 7;11(3):326. doi: 10.3390/pathogens11030326.
The first case of human infection by a species of the Anisakidae family was reported more than 60 years ago. Over the last 20 years, has become a highly studied parasite, not only for its parasitism, but also for its role as an inducer of allergic reactions. Several studies have indicated that the pathological changes occurring within the gastrointestinal tract during infection with are the combined result of the direct action of the larvae invading the tissue and the complex interaction between the host's immune system and the parasite. Although the most commonly described pathologies are digestive, urticaria/angioedema and anaphylaxis, occupational asthma and arthritis have been seldom described. This paper is a narrative of the immune-mediated reaction induced by this parasite over the course of the last two decades.
60多年前就报道了首例人体感染异尖线虫科某种线虫的病例。在过去20年里，它已成为一种得到深入研究的寄生虫，这不仅是因为其寄生特性，还因其作为过敏反应诱导物所起的作用。多项研究表明，感染该线虫期间胃肠道内发生的病理变化是幼虫侵入组织的直接作用以及宿主免疫系统与寄生虫之间复杂相互作用的综合结果。虽然最常描述的病理表现是消化系统症状、荨麻疹/血管性水肿和过敏反应，但职业性哮喘和关节炎很少被提及。本文讲述了过去二十年间由这种寄生虫引发的免疫介导反应。
