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[垂体瘤抗利尿激素分泌不当综合征]

[The syndrome of inappropriate secretion of antidiuretic hormone in hypophyseal tumors].

作者信息

Pontuch P, Vestenická V, Sedlák T, Porubec V, Kinová S, Jezová D

机构信息

I. interná klinika FN, Bratislava.

出版信息

Vnitr Lek. 1998 Feb;44(2):104-7.

PMID:9820085
Abstract

70-year old man was admitted to the hospital due to the sudden change in his behaviour with the production of unusual echolalic word connections. Arginin-vasopressin (AVP) level (1.16 pg/ml) was found inappropriately higher in relation to the severe serum hypoosmolality (261 mmol/kg) and hyponatraemia (117 mmol/l) with relatively high urinary osmolality (590 mmol/kg) and natriuria (684 mmol/24 h). Diagnosis of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH-type C) was confirmed during the water load test. Magnetic resonance imaging and CT scans revealed in the region of hypophysis intrasellar tumour (diameter of 16 mm) and the stabilized finding of temporal cyst. Substitution of sodium losses with the restricted fluid intake resulted in the correction of water-electrolyte balance and the restoration of normal clinical state.

摘要

一名70岁男性因行为突然改变并出现异常的模仿言语性词语连接而入院。发现精氨酸加压素(AVP)水平(1.16 pg/ml)相对于严重的血清低渗(261 mmol/kg)和低钠血症(117 mmol/l)而言过高,同时尿渗透压相对较高(590 mmol/kg)且尿钠排泄量较高(684 mmol/24小时)。在水负荷试验期间确诊为抗利尿激素分泌不当综合征(C型SIADH)。磁共振成像和CT扫描显示垂体窝内有肿瘤(直径16 mm)以及颞叶囊肿的稳定表现。通过限制液体摄入来补充钠流失,从而纠正了水电解质平衡并恢复了正常临床状态。

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