Gordon T, Nadziejko C, Schlesinger R, Chen L C
Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA.
Toxicol Lett. 1998 Aug;96-97:285-8. doi: 10.1016/s0378-4274(98)00084-8.
To examine the biological plausibility of the adverse health effects of ambient particulate matter (PM), we have studied the cardio-pulmonary effects of PM in an animal model of pulmonary hypertension. Normal and monocrotaline-treated rats were exposed, nose-only, for 3 h to filtered air or concentrated ambient PM. At 3 h--but not 24 h--post-exposure, the percentage of neutrophils in peripheral blood was significantly elevated in PM-exposed animals while the percentage of lymphocytes was decreased with no change in white blood cell counts. These changes in white blood cell differential occurred in both normal and monocrotaline-treated animals. Small, but consistent changes in heart rate, but not core temperature, were observed after exposure to concentrated ambient PM. Pulmonary injury, as evidenced by increased protein levels in lavage fluid, occurred only in monocrotaline-treated animals exposed to > 360 microg/m3 PM. The observed pattern of hematological and cardiac changes suggests an activation of the sympathetic stress response.
为了检验环境颗粒物（PM）对健康产生不良影响的生物学合理性，我们在肺动脉高压动物模型中研究了PM对心肺的影响。将正常大鼠和用野百合碱处理过的大鼠仅通过鼻腔暴露于过滤空气或浓缩环境PM中3小时。在暴露后3小时而非24小时，暴露于PM的动物外周血中性粒细胞百分比显著升高，而淋巴细胞百分比降低，白细胞计数无变化。正常大鼠和用野百合碱处理过的大鼠在白细胞分类上均出现了这些变化。暴露于浓缩环境PM后，观察到心率有微小但一致的变化，而核心体温无变化。仅在暴露于>360微克/立方米PM的用野百合碱处理过的动物中出现了肺损伤，这可通过灌洗液中蛋白质水平升高得到证明。观察到的血液学和心脏变化模式表明交感应激反应被激活。
