Khan Z A, Al-Ghamdi S S
Department of Medical Sciences, Faculty of Medicine and Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Int Urol Nephrol. 1998;30(4):499-505. doi: 10.1007/BF02550232.
Male factor infertility, being a complex and heterogeneous disorder, precludes any reliance on a single laboratory test and requires broad spectrum assessment. Sociobiological factors also influence the parameters. In this context we examined serum concentrations of nine hormones in infertile and fertile male Makkans. Infertility was implicated in 21% of the population with correlated abnormalities of gonadotrophins, thyroid, thyroid stimulating hormone (TSH), and testosterone. Hypothyroidism was established in 35% and hyperthyroidism in 14% of the infertile population, where 28% of thyroid abnormality constituted an independent infertile group. Hyperprolactinaemia associated with low levels of luteinizing hormone (LH) and testosterone signifies a cluster of 28%, while 14% of testosterone deficiency alone was causal for infertility. However, infertility in 9% of the patients examined might have been psychogenic in nature. We present a responder panel based on cluster analysis.
男性因素不育是一种复杂的异质性疾病，不能依赖单一的实验室检查，需要进行广泛的评估。社会生物学因素也会影响这些参数。在此背景下，我们检测了不育和可育男性麦加人的九种激素血清浓度。21%的人群存在不育问题，伴有促性腺激素、甲状腺、促甲状腺激素（TSH）和睾酮的相关异常。35%的不育人群患有甲状腺功能减退，14%患有甲状腺功能亢进，其中28%的甲状腺异常构成一个独立的不育组。高催乳素血症与低水平的促黄体生成素（LH）和睾酮相关，占28%，而仅14%的睾酮缺乏是不育的原因。然而，在接受检查的患者中，9%的不育可能是心理性的。我们基于聚类分析提出了一个反应者面板。
