Pomara N, Shao B, Wisniewski T, Mehta P D
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA.
Neurochem Res. 1998 Dec;23(12):1563-6. doi: 10.1023/a:1020936222286.
This report examines plasma amyloid beta proteins A beta 40 and A beta 42 and apolipoprotein E (apoE) levels and their relationships with age in non-demented older adults with (N = 32) or without the apoE-epsilon 4 allele (N = 94). A beta levels did not differ between the groups whereas the epsilon 4 allele was associated with a significant reduction in plasma apoE. In subjects with the epsilon 4 allele, increasing age was associated with significant reduction in plasma A beta 40. Subjects without the epsilon 4 allele showed a significant positive correlation between A beta 40 and A beta 42 levels. There was also a significant correlation between plasma A beta 40 and apoE levels in all subjects.
本报告研究了非痴呆老年人中血浆淀粉样β蛋白Aβ40和Aβ42以及载脂蛋白E（apoE）水平及其与年龄的关系，这些老年人有（N = 32）或没有apoE-ε4等位基因（N = 94）。两组之间的Aβ水平没有差异，而ε4等位基因与血浆apoE的显著降低有关。在携带ε4等位基因的受试者中，年龄增加与血浆Aβ40的显著降低有关。没有ε4等位基因的受试者中，Aβ40和Aβ42水平之间存在显著正相关。在所有受试者中，血浆Aβ40和apoE水平之间也存在显著相关性。
