Yoon D S, Cheong J H, Park Y N, Kwon S W, Chi H S, Kim B R
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1998 Oct;39(5):424-9. doi: 10.3349/ymj.1998.39.5.424.
In the development of a cancer, unlimited cell proliferation has been believed to play an important role. In addition, a programmed cell death called apoptosis, which is regulated by several oncogenes and tumor suppressor genes, has been suggested to be another important different pathway of carcinogenesis. Recently, several reports on cell proliferation capacity and apoptosis in the development of human liver disease have been published, but the cell proliferation index and its relationship between the expression of the bcl-2 and p53 genes involving apoptosis has not yet been discussed in view of the clinical differences of primary and metastatic liver cancer. In this study, we investigated the cell proliferation index and expression of p53 and bcl-2 in the tumorous and non-tumorous portions of both hepatocellular carcinoma and metastatic liver cancer. The expression of p53 was observed in both hepatocellular carcinoma and metastatic liver cancer, but bcl-2 expression was observed neither in hepatocellular carcinoma nor in metastatic liver cancer. In hepatocellular carcinoma, the p53 positive group showed a higher Ki-67 score (cell proliferation index) and more tumor numbers than the p53 negative group (p < 0.05). In metastatic liver cancer, the results were the same as in hepatocellular carcinoma (p < 0.05). However, we could not correlate the p53 expression and its prognostic significance in hepatocellular carcinoma.
在癌症发展过程中，无限的细胞增殖被认为起着重要作用。此外，一种由多种癌基因和肿瘤抑制基因调控的程序性细胞死亡——凋亡，被认为是致癌作用的另一条重要的不同途径。最近，已经发表了几篇关于人类肝脏疾病发展过程中细胞增殖能力和凋亡的报告，但鉴于原发性和转移性肝癌的临床差异，细胞增殖指数及其与涉及凋亡的bcl-2和p53基因表达之间的关系尚未得到讨论。在本研究中，我们调查了肝细胞癌和转移性肝癌肿瘤及非肿瘤部分的细胞增殖指数以及p53和bcl-2的表达。在肝细胞癌和转移性肝癌中均观察到p53的表达，但在肝细胞癌和转移性肝癌中均未观察到bcl-2的表达。在肝细胞癌中，p53阳性组的Ki-67评分（细胞增殖指数）和肿瘤数量均高于p53阴性组（p<0.05）。在转移性肝癌中，结果与肝细胞癌相同（p<0.05）。然而，我们无法将肝细胞癌中p53的表达与其预后意义联系起来。
