通过玻璃体活检聚合酶链反应诊断的里氏综合征患者的三重病毒性视网膜炎。
Triple viral retinitis diagnosed by polymerase chain reaction of the vitreous biopsy in a patient with Richter syndrome.
作者信息
Levinson R D, Hooks J J, Wang Y, Chiu M T, Kellaway J, Chan C C
机构信息
Eye Associates of New Mexico and Southwest Colorado, Albuquerque 87102, USA.
出版信息
Am J Ophthalmol. 1998 Nov;126(5):732-3. doi: 10.1016/s0002-9394(98)00138-x.
PURPOSE
To report the evaluation and identification of herpes viruses associated with retinitis in a patient with Richter syndrome.
METHODS
Diagnostic vitrectomy was performed on a patient with systemic leukemia and retinitis. The vitreous sample was evaluated by cytology, analysis of cytokines by ELISA, and detection of virus by polymerase chain reaction.
RESULTS
The vitreous biopsy specimen showed no malignant cells but predominant CD8+ lymphocyte infiltration with elevated interferon gamma and interleukin-6. DNA amplification and Southern blot analysis demonstrated DNA of herpes simplex, varicella-zoster, and cytomegalovirus.
CONCLUSION
Retinitis associated with multiple viruses in the vitreous biopsy may mimic leukemic infiltration in the eye.
目的
报告对1例Richter综合征患者中与视网膜炎相关的疱疹病毒的评估与鉴定。
方法
对1例患有全身性白血病和视网膜炎的患者进行诊断性玻璃体切割术。通过细胞学、酶联免疫吸附测定法（ELISA）分析细胞因子以及聚合酶链反应检测病毒，对视样进行评估。
结果
玻璃体活检标本未显示恶性细胞，但有以CD8 +淋巴细胞为主的浸润，同时干扰素γ和白细胞介素-6升高。DNA扩增和Southern印迹分析证实了单纯疱疹病毒、水痘-带状疱疹病毒和巨细胞病毒的DNA。
结论
玻璃体活检中与多种病毒相关的视网膜炎可能会模仿眼部的白血病浸润。
Zotero 插件