Suzuki S, Horiguchi M, Tanikawa A, Miyake Y, Kondo M
Department of Ophthalmology, Nagoya University School of Medicine, Japan.
Jpn J Ophthalmol. 1998 Sep-Oct;42(5):424-30. doi: 10.1016/s0021-5155(98)00030-6.
Using a light-emitting diode (LED) built-in contact lens electrode, we studied the effect of age on short-wavelength sensitive cone electroretinograms (S-cone ERG) and long- and middle-wavelength sensitive cone ERGs (LM-cone ERG). We recorded ERGs in 31 pseudophakic subjects to avoid the effect of yellowing in the human crystalline lens. The intensities of our stimuli were on the asymptote of the intensity-response curve. Linear regression analysis against age was carried out on the S-cone ERG b-wave, and the LM-cone ERG a-, b-, and d-waves. We found significant age-dependent reduction in the amplitude of the S-cone ERG b-wave, and the LM-cone ERG a- and d-waves, significant prolongation in the peak time of the S-cone b-wave and the LM-cone ERG b-wave, significant increase in the b/a ratio of the LM-cone ERG, but no significant age correlation between the LM-cone ERG a-wave and the amplitude of the b-wave. Our results provide evidence that age-related changes in S- and LM-cone systems begin in early adulthood in the human eye. A significant increase in the b/a ratio suggests that off-bipolar cells are more vulnerable to aging than on-bipolar cells.
我们使用内置发光二极管（LED）的隐形眼镜电极，研究了年龄对短波长敏感视锥细胞视网膜电图（S-视锥细胞ERG）以及长波长和中波长敏感视锥细胞视网膜电图（LM-视锥细胞ERG）的影响。我们记录了31例人工晶状体眼受试者的视网膜电图，以避免人晶状体变黄的影响。我们的刺激强度处于强度-反应曲线的渐近线上。对S-视锥细胞ERG的b波、LM-视锥细胞ERG的a波、b波和d波进行了与年龄的线性回归分析。我们发现，S-视锥细胞ERG的b波、LM-视锥细胞ERG的a波和d波的振幅随年龄显著降低，S-视锥细胞b波和LM-视锥细胞ERG的b波的峰值时间显著延长，LM-视锥细胞ERG的b/a比值显著增加，但LM-视锥细胞ERG的a波与b波振幅之间无显著的年龄相关性。我们的结果提供了证据，表明S-视锥细胞和LM-视锥细胞系统与年龄相关的变化在人眼成年早期就开始了。b/a比值的显著增加表明，离极双极细胞比ON-双极细胞更容易受到衰老的影响。
