Luczynska C, Sterne J, Bond J, Azima H, Burney P
Department of Public Health Sciences, Guy's and St Thomas' School of Medicine, King's College, London, UK.
Clin Exp Allergy. 1998 Oct;28(10):1201-9. doi: 10.1046/j.1365-2222.1998.00410.x.
Studies of house dust mite allergen concentrations suggest large variations both within and between homes. It is likely that different household characteristics influence allergen levels in different locations within the house.
To investigate household characteristics associated with higher concentrations of house dust mite allergen in a random sample of houses.
Information on indoor environment was obtained from 158 adults aged 20-44. Dust samples were collected from their living room floor, bedroom floor and mattress. Concentrations of Der p 1, the major allergen from the house dust mite Dermatophagoides pteronyssinus, were measured by monoclonal antibody immunoassay. Associations between mite allergen concentrations and household characteristics were examined using censored-normal regression models. Factors that were related to Der p 1 (P </= 0.2) in univariate analyses were included in multivariable regression models.
Der p 1 was not detected in any location in 10 (6.3%) houses. Geometric mean concentrations of Der p 1 were 1.9 microg/g in living room floor dust, 1.7 microg/g in bedroom floor dust and 2.0 microg/g in mattress dust. Approximately 25% of living room floor and mattress, and over 30% of bedroom floor samples had Der p 1 concentrations greater than 10 microg/g. Household characteristics associated with Der p 1 concentrations in both living room and bedroom were floor level, extractor fan in the kitchen, and age of carpet. Living room Der p 1 concentrations were also associated with gas oven/hob, window condensation, open fires, vacuum cleaner type, smokers in the house and age of house. Bedroom Der p 1 concentrations were also associated with use of blankets and wash temperature of bedding. Mattress Der p 1 concentrations were associated with window condensation, concrete bedroom floor and age of mattress.
Different household characteristics were associated with high Der p 1 concentrations in different parts of the house. These findings are relevant to design of allergen avoidance regimes or formulation of policy recommendations for reduction of disease associated with allergen exposure.
对屋尘螨过敏原浓度的研究表明，家庭内部和家庭之间存在很大差异。不同的家庭特征可能会影响房屋内不同位置的过敏原水平。
在随机抽取的一组房屋样本中，调查与屋尘螨过敏原浓度较高相关的家庭特征。
从158名年龄在20 - 44岁的成年人那里获取室内环境信息。从他们客厅地板、卧室地板和床垫上采集灰尘样本。通过单克隆抗体免疫测定法测量屋尘螨嗜热栖尘螨的主要过敏原Der p 1的浓度。使用删失正态回归模型检查螨过敏原浓度与家庭特征之间的关联。单变量分析中与Der p 1相关（P≤0.2）的因素被纳入多变量回归模型。
10所房屋（6.3%）的任何位置均未检测到Der p 1。Der p 1在客厅地板灰尘中的几何平均浓度为1.9微克/克，在卧室地板灰尘中为1.7微克/克，在床垫灰尘中为2.0微克/克。约25%的客厅地板和床垫样本以及超过30%的卧室地板样本中Der p 1浓度大于10微克/克。与客厅和卧室中Der p 1浓度相关的家庭特征包括楼层、厨房抽油烟机、地毯使用年限。客厅Der p 1浓度还与燃气烤箱/炉灶、窗户结露、明火、吸尘器类型、房屋内吸烟者以及房屋使用年限有关。卧室Der p 1浓度还与使用毛毯和床上用品洗涤温度有关。床垫Der p 1浓度与窗户结露、卧室混凝土地板以及床垫使用年限有关。
不同的家庭特征与房屋不同部位Der p 1的高浓度有关。这些发现对于设计过敏原规避方案或制定减少与过敏原暴露相关疾病的政策建议具有重要意义。
