幽门螺杆菌在体内会导致附着的胃黏液层发生结构变化，但屏障厚度并未受损。
Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised.
作者信息
Newton J L, Jordan N, Oliver L, Strugala V, Pearson J, James O F, Allen A
机构信息
Department of Physiological Sciences, University of Newcastle-upon- Tyne, UK.
出版信息
Gut. 1998 Oct;43(4):470-5. doi: 10.1136/gut.43.4.470.
BACKGROUND
It has been proposed that a pathogenic effect of Helicobacter pylori is a weakening of the protective mucus barrier; however, this remains controversial.
AIMS
To clarify the effects of H pylori infection on the mucus gel barrier in vivo.
METHODS
Mucus gel polymeric structure and the thickness of the adherent mucus barrier were measured in endoscopic biopsy samples in subjects with and without H pylori infection.
RESULTS
There was a significant 18% reduction in the proportion of polymeric gel forming mucin in the adherent mucus layer in H pylori positive compared with negative subjects. There was no change in the adherent mucus thickness between H pylori positive and negative subjects without gastric atrophy (mean (SD): 104 (26) micron, 106 (30) micron, respectively). There was however a significant reduction in mucus thickness in those H pylori positive subjects with underlying gastric atrophy (84 (13) micron, p=0.03) compared with those without atrophy.
CONCLUSIONS
A partial breakdown in gel forming structure of the gastric mucus barrier does occur in H pylori infection per se but this is insufficient to cause a collapse of the mucus barrier.
背景
有人提出幽门螺杆菌的致病作用是削弱保护性黏液屏障；然而，这一点仍存在争议。
目的
阐明幽门螺杆菌感染对体内黏液凝胶屏障的影响。
方法
在有或无幽门螺杆菌感染的受试者的内镜活检样本中，测量黏液凝胶的聚合结构和附着黏液屏障的厚度。
结果
与幽门螺杆菌阴性受试者相比，阳性受试者附着黏液层中形成聚合物凝胶的黏蛋白比例显著降低了18%。在无胃萎缩的幽门螺杆菌阳性和阴性受试者之间，附着黏液厚度没有变化（平均值（标准差）分别为104（26）微米和106（30）微米）。然而，与无萎缩的幽门螺杆菌阳性受试者相比，有潜在胃萎缩的幽门螺杆菌阳性受试者的黏液厚度显著降低（84（13）微米，p = 0.03）。
结论
幽门螺杆菌感染本身确实会导致胃黏液屏障的凝胶形成结构部分破坏，但这不足以导致黏液屏障崩溃。
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